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Study objective: To evaluate the association between use of methadone, other central nervous system CNS depressants, and QTc interval-prolonging medications and risk of mortality among human immunodeficiency virus HIV -infected and at-risk HIV-uninfected women. Measurements and main : Data on medication utilization were collected from all study participants via interviewer-administered surveys at 6-month intervals Mortality was confirmed by National Death Index data.

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With age defining the time scale for the analysis, Cox proportional hazards models were used to estimate hazard ratios HRs for all-cause mortality in HIV-infected and -uninfected women and non-acquired immunodeficiency syndrome AIDS deaths in HIV-infected women. A total of deaths were identified, of which were considered non-AIDS deaths.

Use of benzodiazepines, CNS depressants excluding methadoneand of medications with conditional QTc interval-prolonging effects were each associated with all-cause mortality in multivariate models of HIV-infected women: hazard ratio HR 1. Conclusion: In this cohort of HIV-infected and at-risk HIV-uninfected women, use of benzodiazepines, CNS depressants, and conditional QTc interval-prolonging medications were associated with a higher risk of mortality independent of methadone and other well-recognized mortality risk factors.

Care must be taken to assess risk when prescribing these medications in this underserved and at-risk patient population. Keywords: HIV infections; arrhythmias cardiac; benzodiazepines; central nervous system depressants; methadone; mortality.

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Methadone: how it works and why it’s legal

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Association between use of methadone, other central nervous system depressants, and qtc interval-prolonging medications and risk of mortality in a large cohort of women living with or at risk for human immunodeficiency virus infection

Which day? Send at most: 1 item 5 items 10 items 20 items 50 items items items. Send even when there aren't any new. Optional text in :. Save Cancel. Create a file for external citation management software Create file Cancel. of items displayed: 5 10 15 20 50 Create RSS Cancel. RSS Link Copy. Full text links Cite Display options Display options. Abstract Study objective: To evaluate the association between use of methadone, other central nervous system CNS depressants, and QTc interval-prolonging medications and risk of mortality among human immunodeficiency virus HIV -infected and at-risk HIV-uninfected women.

Figures Figure 1. Medication combinations that can increase…. Figure 1.

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Medication combinations that can increase the risk of central nervous system depression and…. Medication combinations that can increase the risk of central nervous system depression and levels of each drug interaction.

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Ann Intern Med. PMID: Mortality in an urban cohort of HIV-infected and at-risk drug users in the era of highly active antiretroviral therapy. Kohli R, et al. Clin Infect Dis. Epub Aug Mortality in HIV-infected women, heterosexual men, and men who have sex with men in Rio de Janeiro, Brazil: an observational cohort study.

Coelho L, et al.

What is methadone?

Lancet HIV. Cause-specific life expectancies after 35 years of age for human immunodeficiency syndrome-infected and human immunodeficiency syndrome-negative individuals followed simultaneously in long-term cohort studies, Wada N, et al. Am J Epidemiol. Epub Jan 3. Causes of death among women with human immunodeficiency virus infection in the era of combination antiretroviral therapy. Cohen MH, et al. Am J Med. See all similar articles.

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Chichetto NE, et al. Publication types Multicenter Study Actions. Observational Study Actions. Research Support, N. Adolescent Actions. Adult Actions. Aged Actions. CD4 Lymphocyte Count Actions. Cause of Death Actions. Female Actions. Humans Actions. Kidney Function Tests Actions. Middle Aged Actions. Proportional Hazards Models Actions. Prospective Studies Actions. Risk Factors Actions. Sexual Behavior Actions.

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Socioeconomic Factors Actions. Viral Load Actions. Young Adult Actions. Hemoglobins Actions. Serum Albumin Actions. Benzodiazepines Actions.

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Methadone Hydrochloride Oral Concentrate is a mu-agonist, a synthetic opioid analgesic , indicated for detoxification treatment of opioid addiction heroin or other morphine -like drugs , and for maintenance treatment of opioid addiction heroin or other morphine-like drugs , in conjunction with appropriate social and medical services.
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Reading, engaging with, and sharing our publications, papers and commentary gives evidence-based science and policy the audience it needs and deserves.
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There has been a lot of recent media attention on methadone, emphasising a range of factually incorrect messages.
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