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Be especially watchful for these symptoms when a new antidepressant is started or when the dose is changed. Uses Sertraline is used to treat depressionpanic attacksobsessive compulsive disorderpost-traumatic stress disorder, social anxiety disorder social phobiaand a severe form of premenstrual syndrome premenstrual dysphoric disorder. This medication may improve your mood, sleepappetite, and energy level and may help restore your interest in daily living. It may decrease fear, anxietyunwanted thoughts, and the of panic attacks.


for the latest news from SHM Converge. There are multiple reasons for crushing tablets or capsule contents before administering medications, but there are numerous medications that should not be crushed. These medications should not be chewed, either, usually due to their specific formulations and their pharmacokinetic properties.

Legal category

The majority of extended-release products should not be crushed or chewed, although there are some newer slow-release tablet formulations available that are scored and can be divided or halved e. A common reason for crushing a tablet or capsule is for use by a hospitalized patient with an enteral feeding tube.

A recent review in the American Journal of Health-System Pharmacy provides more details about administering medications in patients with enteral feeding tubes. If an oral solution or suspension is not available, the hospital pharmacy should be consulted to determine if a liquid formulation of the product can be extemporaneously prepared.

Active ingredient

In some cases, after careful consideration of compatibility, stability, and drug absorption changes, an injectable formulation of a product may be used. You should always consult your hospital pharmacist for information on this modality of drug administration. Some patients have difficulty swallowing tablets or capsules; some dislike the taste. In these cases, crushing of medication for powdered delivery to be mixed with food or beverages should be considered. But beware of certain caveats, as not all medications are suitable for crushing.

Generally, meds that should not be crushed fall into one of these :. Other medications have objectionable tastes and are sugar-coated to improve tolerability.

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If this type of medication is crushed, the patient would be subject to its unpleasant taste, which could ificantly impair medication adherence. If there is ever any doubt about the best way to administer a particular product or whether it can be halved or crushed, ask your pharmacist. Michele B. Cinryze, a C1 esterase inhibitor humanis FDA-approved as a new orphan drug for routine prophylaxis against angioedema in patients with hereditary angioedema HAE.

Granisetron 3. A patch may be worn for up to seven days. They should not be cut. The most common adverse reactions in clinical trials were diplopia, headache, dizziness, and nausea.

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Both the oral tablets and the IV infusion are bioequivalent. Mesalamine extended-release 0. The recommended dose is four capsules 1. Because release of the active drug is pH-dependent, it should not be administered with antacids. Ranolazine Ranexa is FDA-approved as an initial treatment for chronic angina. Quetiapine extended-release tablets Seroquel XR are FDA-approved to treat depressive episodes in bipolar disorder, manic and mixed episodes in bipolar I disorder, and the maintenance treatment of bipolar I disorder as adjunct therapy to lithium or divalproex.

It is available in two new dosage strengths, and mg tablets. There have been more than 1, serious adverse events—including 50 deaths—associated with the use of varenicline Chantix since its approval in Mitchell J. Oral dosage forms that should not be crushed or chewed: facts and comparisons 4.

Side effects

Hospital Pharmacy Web site. Available at: online. Accessed March 5, Williams NT. Medication administration through enteral feeding tubes. Am J Health Syst Pharm. Mitchell JF. Wolters Kluwer Health Web site. Available at: www. Accessed Jan. Mylan's Matrix receives final FDA approval for the generic version of the antiretroviral Zerit capsules. Product approval information.

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Food and Drug Administration Web site. FDA s for marketing new therapy for rare genetic disease.

What to do instead of crushing

Sancuso patch approved for nausea and vomiting. Monthly Prescribing Reference Web site. TussiCaps now available for cough suppression. FDA as adjunctive therapy for partial onset seizures in adults. Medical News Today Web site. Apriso granted FDA marketing approval for maintenance of remission of ulcerative colitis. Accessed February 2, FDA approves Seroquel for bipolar maintenance.

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Seroquel XR Web site. Peck P. Smoking cessation drug linked to 1, new serious adverse events.

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Med Today Web site. Public health advisory: important information on Chantix varenicline. Medicolegal Issues.

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To Crush or Not to Crush. The Hospitalist. Author s : Michele B. Generally, meds that should not be crushed fall into one of these : Sustained-release tablets, which can be composed of multiple layers for different drug release times, as can be within capsules.

"don't rush to crush"

Enteric-coated tablets, which are formulated because certain drugs can be irritating to the stomach or are degraded by stomach acid. Prefixes include EN- and EC. New Warnings There have been more than 1, serious adverse events—including 50 deaths—associated with the use of varenicline Chantix since its approval in Next Article: Eliminate Inconsistency.

Practice Management Major insurers running billions of dollars behind on payments to hospitals and doctors Publish date: October 8, From the Society Mean leadership Publish date: September 23, Matt Aldrich Publish date: March 30, Menu Close.

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Generic drugs usually cost less.


This leaflet is about the use of sertraline for obsessive compulsive disorder which is often shortened to OCD and depression in children.


If you or someone you look after is finding it hard to swallow tablets or capsules solid medicines , you might think that the answer is to crush a tablet or open a capsule to make swallowing medication easier.


It is written for patients and gives information about taking or using a medicine.